Synthesis of some new Pyrazoline Carbothioamides and Pyrimidinethiols Derivatives from Bis-α, β-Unsaturated Carbonyl Compounds

In our research, new bis-α, β-unsaturated carbonyl compounds (Z2-Z4) were prepared via Claisen- Schmidt reaction, by the condensation of 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine (Z1) with different appropriate benzaldehyde, like (benzaldehyde, m-nitro benzaldehyde and o-chloro benzaldehyde) using 10% aqueous sodium hydroxide as a base. A simple efficient method has been applied for synthesis 2,6-dimethyl- 3,5-diacetyl-1,4-dihydropyridine multi components Rudolf-Hantzsch reaction which included heating starting materials (paraformaldehyde, acetylacetone ammonium acetate) at 80Cͦ degrees centigrade in medium. Bis-α, can be considered useful intermediates leading to formation several heterocyclic such pyrazoline carbothioamide (Z5-Z7) pyrimidinethiole (Z8-Z10). The titled (Z8-Z10) interacting thiosemicarbazide neutral medium, thiourea basic medium respectively. These mentioned (Z1-Z10) characterized Ferrier Translate-Infrared spectrum (FT-IR) Ultraviolet (UV), addition some physical properties. Also, all these reactions followed thin layer chromatography (TLC) technique calculate retardation factor (Rf) values.